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DBT soon to begin research on regeneration of organs like heart, liver, whole tooth, eye, etc

Ramesh Shankar, Mumbai
Friday, December 22, 2017, 08:00 Hrs  [IST]

The Department of Biotechnology (DBT) will soon begin research on organ regeneration, especially on organs such as heart, liver pancreas, whole tooth, eye, etc.

The DBT's research initiative in this direction is important as tissue engineering has become an established protocol for the bioengineering of living tissues using engineered scaffolds to simulate the ECM so that cells can populate the scaffold and allow for tissue regeneration. The success of tissue engineering methods has now generated strong interest in the next level of whole organ development wherein the tools of tissue engineering are integrated with engineering and process technologies, molecular biology and developmental biology to generate working organs that can have sufficient survivability to either serve as a bridge to transplant or as a replacement organ itself. This effort is a significantly multidisciplinary and ideally multi institutional effort that brings together various complementary expertise in a mission mode with the specific goal of translating the results to clinical trials.

DBT is now calling for such multi institutional and multidisciplinary concept proposals on organ regeneration. A minimum of 3 Institutes should be involved as a team. At least one of the institutions must be a medical institution and at least one of the principal investigators (PIs) must be a clinician.  The DBT has identified seven candidate organs for development for this call. They are heart; liver; pancreas; skin; bone integrated with muscle, tendon and marrow; whole tooth; and  eye. Though the DBT has identified only seven candidate organs for this call, the teams may propose some other organ, provided there is a clear credible evidence for such a choice.

Eligible institutions can submit the concept proposal by December 26, 2017.


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